WebAbstract. The role of glutathione (GSH) in protecting plants from chilling injury was analyzed in seedlings of a chilling-tolerant maize (Zea mays L.) genotype using buthionine … WebApr 5, 2016 · Consistent with this prediction, inhibition of glutamate-cysteine ligase (GCL, formerly known as γ-glutamylcysteine synthetase), the rate-limiting first enzyme in the two-step synthesis of GSH, using buthionine-(S,R)-sulfoximine (BSO ), can induce cell death that is suppressed by α-tocopherol and DFO, but not by the caspase inhibitor zVAD-fmk ...
mTORC1 couples cyst(e)ine availability with GPX4 protein ... - Nature
WebAn inhibitor of GSH synthesis, buthionine sulfoximine (BSO), sensitized Cal-27 and SCC-25 cells to PER-induced clonogenic killing as well as decreased total GSH and increased … WebFeb 4, 2024 · By using the specific (h)GSH synthesis inhibitor BSO , as well as mutant lines, the role of (h)GSH in H 2-induced Cd tolerance was demonstrated. The results showed that in alfalfa, glutathione depletion by BSO inhibited seedling growth, which also blocked the alleviation of Cd stress by HRW (Fig. 4 a, b). teams mark all chats as read
Influence of buthionine sulfoximine, S …
WebSep 29, 2024 · BSO is an inhibitor of GSH synthase that has been used to deplete GSH in vitro, including in macrophages (11, 12), and is more specific than GSH-depleting agents such as diethylmaleate that can activate nrf2 directly due to its electrophilic properties . WebOct 1, 1984 · Buthionine sulphoximine (BSO) is an inhibitor of gamma-glutamylcysteine synthetase (gamma-GCS) and, consequently lowers tissue … WebDec 1, 1994 · Measurement of intracellular glutathione (GSH) levels in peripheral mononuclear cells (PBLs) of all patients receiving BSO showed a consistent, non-dose … teams manifest schema permissions