Web12 de dez. de 2024 · Inhibition of mTORC1 by mTOR inhibitors may promote autophagy of infected cells and inhibit translation of SARS-CoV-2 viral polymerase and structural proteins. mTOR, mammalian target of rapamycin; SARS-CoV … Web8 de jul. de 2024 · We examined the effects of mTOR inhibitors on the fibrotic response induced by transforming growth factor-beta2 (TGF-β2) in cultured human trabecular meshwork (hTM) cells. TGF-β2-induced ...
mTOR信号通路调节HIF-1α及VEGF.pdf-综合论文-全文在线 ...
WebWe identified four pathways, ErbB, HIF-1, mTOR and TNF signaling, among others that were markedly modulated during the course of the SARS-CoV-2 infection in vitro. Western blot validation of the downstream effector molecules of these pathways revealed a dose-dependent activation of Akt, mTOR, S6K1 and 4E-BP1 at 24 hours post infection (hpi). Web23 de abr. de 2015 · We therefore proposed that mTORC1 drives HIF-1α synthesis in a multifaceted manner through 4E-BP1/eIF4E, S6K1 and STAT3. Interestingly, we … nova health laramie
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Web23 de mai. de 2004 · Majumder, P., Febbo, P., Bikoff, R. et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF … WebHIF-1-alpha 1 publication ; HIF1-alpha 1 publication Alternative names ARNT-interacting protein Basic-helix-loop-helix-PAS protein MOP1 1 publication Class E basic helix-loop-helix protein 78 ( bHLHe78) Member of PAS protein 1 1 publication PAS domain-containing protein 8 Gene names Name HIF1A 1 publication Imported Synonyms BHLHE78, MOP1 Web30 de jul. de 2024 · Under normoxia, HIF-1α is hydroxylated by prolyl-4-hydroxylase (PHD) and factor inhibiting HIF-1 (FIH), and interacts with von Hippel-Lindau (VHL), resulting in the degradation by the proteasome.... how to sink my phone to my computer