High chloride load was also associated with increased odds of ICU mortality. Our best performing supervised learning model predicted second-day hyperchloremia with an AUC of 0.76 and a number needed to alert (NNA) of 7—a clinically-actionable rate. Meer weergeven All chloride-related features that we initially selected were included by default. The following features were also included as they showed … Meer weergeven Performance was similar across all four classifiers. The multi-layer perceptron had the highest AUC (0.76) and highest area under the precision-recall curve (0.19). With the … Meer weergeven GridSearchCV from the scikit-learn [29] library selected hyperparameters for all classifiers though some variables, increments, and boundaries were manually … Meer weergeven Ridge regression coefficients with magnitude greater than 0.2 are reported in Table 5. As we can see, maximum serum chloride on day 1 had the largest influence. … Meer weergeven WebHyperchloremia is a repeated insult in critically ill subjects, leading to more morbidity and mortality. There is a strong relation between hyperchloremia with mortality and morbidity, as renal injury, more extended ICU stay, more mechanical ventilation (MV) period, and other electrolyte disturbances.
Saline versus 5% dextrose in water as a drug diluent for critically ill ...
Web21 mei 2024 · Hyperchloremia in the ICU may occur because of disease processes or secondary to therapeutic interventions [7,19,21]. Excessive water loss - either net water loss or in excess of chloride loss - is another causative mechanism, like diuretic use and osmotic diuresis, which are common in neurocritical patients [ 26 ]. Web20 dec. 2024 · The primary outcome was incidence of hyperchloremia (chloride >109 mEq/L). Secondary outcomes included incidence of severe hyperchloremia (chloride >115 mEq/L), incidence of acute kidney injury (AKI), need for renal replacement therapy (RRT), intensive care unit (ICU) length of stay (LOS), hospital LOS, and in-hospital mortality. frnch paris sweater
Association of Hyperchloremia With Hospital Mortality in Cri
WebIt has been reported in up to 80% of patients in a mixed medical-surgical ICU. ‘Severe’ hyperchloremia ([Cl –] > 114 mol/L) occurs less frequently (around 6% in one recent report), and the ... Web11 sep. 2024 · Hyperchloremia was defined as ≥ 110 mmol/L [ 5, 6, 15 ]. With respect to sodium, chloride, and blood glucose, the values at the time of ICU admission were defined as the baseline. With respect to creatinine, we defined the baseline value as the mean serum creatinine level measured 7 to 365 days before hospital admission [ 16 ]. Web4 okt. 2016 · Background Chloride is important for maintaining acid-base balance, muscular activity, osmosis and immunomodulation. In patients with major trauma, chloride levels increase after fluid therapy; this is associated with poor clinical outcomes. The purpose of this study was to determine whether hyperchloremia was associated with increased … fc玉島